Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing
Identifieur interne : 000058 ( Main/Exploration ); précédent : 000057; suivant : 000059Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing
Auteurs : Prathish K. Rajaraman [États-Unis] ; Jiwoong Choi [États-Unis] ; Eric A. Hoffman [États-Unis] ; Patrick T. O'Shaughnessy [États-Unis] ; Sanghun Choi [Corée du Sud] ; Renishkumar Delvadia [États-Unis] ; Andrew Babiskin [États-Unis] ; Ross Walenga [États-Unis] ; Ching-Long Lin [États-Unis]Source :
- Journal of Aerosol Science [ 0021-8502 ] ; 2020.
Abstract
This study numerically investigates the effect of hygroscopicity on transport and deposition of particles in severe asthmatic lungs with distinct airway structures. The study human subjects were selected from two imaging-based severe asthmatic clusters with one characterized by non-constricted airways and the other by constricted airways in the lower left lobe (LLL). We compared the deposition fractions of sodium chloride (NaCl) particles with a range of aerodynamic diameters (1–8 μm) in cluster archetypes under conditions with and without hygroscopic growth. The temperature and water vapor distributions in the airways were simulated with an airway wall boundary condition that accounts for variable temperature and water vapor evaporation at the interface between the lumen and the airway surface liquid layer. On average, the deposition fraction increased by about 6% due to hygroscopic particle growth in the cluster subjects with constricted airways, while it increased by only about 0.5% in those with non-constricted airways. The effect of particle growth was most significant for particles with an initial diameter of
Url:
DOI: 10.1016/j.jaerosci.2020.105581
PubMed: 32346183
PubMed Central: 7187883
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000694
- to stream Pmc, to step Curation: 000694
- to stream Pmc, to step Checkpoint: 000034
- to stream Ncbi, to step Merge: 001095
- to stream Ncbi, to step Curation: 001095
- to stream Ncbi, to step Checkpoint: 001095
- to stream Main, to step Merge: 000058
- to stream Main, to step Curation: 000058
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing</title><author><name sortKey="Rajaraman, Prathish K" sort="Rajaraman, Prathish K" uniqKey="Rajaraman P" first="Prathish K." last="Rajaraman">Prathish K. Rajaraman</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Mechanical Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Choi, Jiwoong" sort="Choi, Jiwoong" uniqKey="Choi J" first="Jiwoong" last="Choi">Jiwoong Choi</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Mechanical Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Hoffman, Eric A" sort="Hoffman, Eric A" uniqKey="Hoffman E" first="Eric A." last="Hoffman">Eric A. Hoffman</name><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Radiology, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="O Shaughnessy, Patrick T" sort="O Shaughnessy, Patrick T" uniqKey="O Shaughnessy P" first="Patrick T." last="O'Shaughnessy">Patrick T. O'Shaughnessy</name><affiliation wicri:level="4"><nlm:aff id="aff4">Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Choi, Sanghun" sort="Choi, Sanghun" uniqKey="Choi S" first="Sanghun" last="Choi">Sanghun Choi</name><affiliation wicri:level="1"><nlm:aff id="aff5">School of Mechanical Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Mechanical Engineering, Kyungpook National University, Daegu, 41566</wicri:regionArea><wicri:noRegion>41566</wicri:noRegion></affiliation></author><author><name sortKey="Delvadia, Renishkumar" sort="Delvadia, Renishkumar" uniqKey="Delvadia R" first="Renishkumar" last="Delvadia">Renishkumar Delvadia</name><affiliation wicri:level="2"><nlm:aff id="aff6">Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Babiskin, Andrew" sort="Babiskin, Andrew" uniqKey="Babiskin A" first="Andrew" last="Babiskin">Andrew Babiskin</name><affiliation wicri:level="2"><nlm:aff id="aff6">Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Walenga, Ross" sort="Walenga, Ross" uniqKey="Walenga R" first="Ross" last="Walenga">Ross Walenga</name><affiliation wicri:level="2"><nlm:aff id="aff6">Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lin, Ching Long" sort="Lin, Ching Long" uniqKey="Lin C" first="Ching-Long" last="Lin">Ching-Long Lin</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Mechanical Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32346183</idno><idno type="pmc">7187883</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187883</idno><idno type="RBID">PMC:7187883</idno><idno type="doi">10.1016/j.jaerosci.2020.105581</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000694</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000694</idno><idno type="wicri:Area/Pmc/Curation">000694</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000694</idno><idno type="wicri:Area/Pmc/Checkpoint">000034</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000034</idno><idno type="wicri:Area/Ncbi/Merge">001095</idno><idno type="wicri:Area/Ncbi/Curation">001095</idno><idno type="wicri:Area/Ncbi/Checkpoint">001095</idno><idno type="wicri:doubleKey">0021-8502:2020:Rajaraman P:transport:and:deposition</idno><idno type="wicri:Area/Main/Merge">000058</idno><idno type="wicri:Area/Main/Curation">000058</idno><idno type="wicri:Area/Main/Exploration">000058</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing</title><author><name sortKey="Rajaraman, Prathish K" sort="Rajaraman, Prathish K" uniqKey="Rajaraman P" first="Prathish K." last="Rajaraman">Prathish K. Rajaraman</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Mechanical Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Choi, Jiwoong" sort="Choi, Jiwoong" uniqKey="Choi J" first="Jiwoong" last="Choi">Jiwoong Choi</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Mechanical Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Hoffman, Eric A" sort="Hoffman, Eric A" uniqKey="Hoffman E" first="Eric A." last="Hoffman">Eric A. Hoffman</name><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Radiology, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="O Shaughnessy, Patrick T" sort="O Shaughnessy, Patrick T" uniqKey="O Shaughnessy P" first="Patrick T." last="O'Shaughnessy">Patrick T. O'Shaughnessy</name><affiliation wicri:level="4"><nlm:aff id="aff4">Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Choi, Sanghun" sort="Choi, Sanghun" uniqKey="Choi S" first="Sanghun" last="Choi">Sanghun Choi</name><affiliation wicri:level="1"><nlm:aff id="aff5">School of Mechanical Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Mechanical Engineering, Kyungpook National University, Daegu, 41566</wicri:regionArea><wicri:noRegion>41566</wicri:noRegion></affiliation></author><author><name sortKey="Delvadia, Renishkumar" sort="Delvadia, Renishkumar" uniqKey="Delvadia R" first="Renishkumar" last="Delvadia">Renishkumar Delvadia</name><affiliation wicri:level="2"><nlm:aff id="aff6">Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Babiskin, Andrew" sort="Babiskin, Andrew" uniqKey="Babiskin A" first="Andrew" last="Babiskin">Andrew Babiskin</name><affiliation wicri:level="2"><nlm:aff id="aff6">Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Walenga, Ross" sort="Walenga, Ross" uniqKey="Walenga R" first="Ross" last="Walenga">Ross Walenga</name><affiliation wicri:level="2"><nlm:aff id="aff6">Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lin, Ching Long" sort="Lin, Ching Long" uniqKey="Lin C" first="Ching-Long" last="Lin">Ching-Long Lin</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Mechanical Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>IIHR-Hydroscience and Engineering, The University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author></analytic><series><title level="j">Journal of Aerosol Science</title><idno type="ISSN">0021-8502</idno><idno type="eISSN">0021-8502</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study numerically investigates the effect of hygroscopicity on transport and deposition of particles in severe asthmatic lungs with distinct airway structures. The study human subjects were selected from two imaging-based severe asthmatic clusters with one characterized by non-constricted airways and the other by constricted airways in the lower left lobe (LLL). We compared the deposition fractions of sodium chloride (NaCl) particles with a range of aerodynamic diameters (1–8 μm) in cluster archetypes under conditions with and without hygroscopic growth. The temperature and water vapor distributions in the airways were simulated with an airway wall boundary condition that accounts for variable temperature and water vapor evaporation at the interface between the lumen and the airway surface liquid layer. On average, the deposition fraction increased by about 6% due to hygroscopic particle growth in the cluster subjects with constricted airways, while it increased by only about 0.5% in those with non-constricted airways. The effect of particle growth was most significant for particles with an initial diameter of <inline-formula><mml:math id="M1" altimg="si1.svg"><mml:mrow><mml:mn>2</mml:mn><mml:mtext> μm</mml:mtext></mml:mrow></mml:math></inline-formula> in the cluster subjects with constricted airways. The effect diminished with increasing particle size, especially for particles with an initial diameter larger than 4 μm. This suggests the necessity to differentiate asthmatic subjects by cluster in engineering the aerosol size for tailored treatment. Specifically, the treatment of severe asthmatic subjects who have constricted airways with inhalation aerosols may need submicron-sized hygroscopic particles to compensate for particle growth, if one targets for delivering to the peripheral region. These results could potentially inform the choice of particle size for inhalational drug delivery in a cluster-specific manner.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Asgharian, B" uniqKey="Asgharian B">B. Asgharian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asgharian, B" uniqKey="Asgharian B">B. Asgharian</name></author><author><name sortKey="Rostami, A A" uniqKey="Rostami A">A.A. Rostami</name></author><author><name sortKey="Price, O T" uniqKey="Price O">O.T. Price</name></author><author><name sortKey="Pithawalla, Y B" uniqKey="Pithawalla Y">Y.B. Pithawalla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borgstrom, L" uniqKey="Borgstrom L">L. Borgström</name></author><author><name sortKey="Bengtsson, T" uniqKey="Bengtsson T">T. Bengtsson</name></author><author><name sortKey="Derom, E" uniqKey="Derom E">E. Derom</name></author><author><name sortKey="Pauwels, R" uniqKey="Pauwels R">R. Pauwels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Broday, D M" uniqKey="Broday D">D.M. Broday</name></author><author><name sortKey="Georgopoulos, P G" uniqKey="Georgopoulos P">P.G. Georgopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Byron, P R" uniqKey="Byron P">P.R. Byron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y. Feng</name></author><author><name sortKey="Zhong, W" uniqKey="Zhong W">W. Zhong</name></author><author><name sortKey="Kleinstreuer, C" uniqKey="Kleinstreuer C">C. Kleinstreuer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Kleinstreuer, C" uniqKey="Kleinstreuer C">C. Kleinstreuer</name></author><author><name sortKey="Zhong, W" uniqKey="Zhong W">W. Zhong</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y. Feng</name></author><author><name sortKey="Zhou, X" uniqKey="Zhou X">X. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Ma, R" uniqKey="Ma R">R. Ma</name></author><author><name sortKey="Zhong, W" uniqKey="Zhong W">W. Zhong</name></author><author><name sortKey="Sun, B" uniqKey="Sun B">B. Sun</name></author><author><name sortKey="Zhou, X" uniqKey="Zhou X">X. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, S" uniqKey="Choi S">S. Choi</name></author><author><name sortKey="Hoffman, E A" uniqKey="Hoffman E">E.A. Hoffman</name></author><author><name sortKey="Wenzel, S E" uniqKey="Wenzel S">S.E. Wenzel</name></author><author><name sortKey="Castro, M" uniqKey="Castro M">M. Castro</name></author><author><name sortKey="Fain, S" uniqKey="Fain S">S. Fain</name></author><author><name sortKey="Jarjour, N" uniqKey="Jarjour N">N. Jarjour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, J" uniqKey="Choi J">J. Choi</name></author><author><name sortKey="Leblanc, L J" uniqKey="Leblanc L">L.J. LeBlanc</name></author><author><name sortKey="Choi, S" uniqKey="Choi S">S. Choi</name></author><author><name sortKey="Haghighi, B" uniqKey="Haghighi B">B. Haghighi</name></author><author><name sortKey="Hoffman, E A" uniqKey="Hoffman E">E.A. Hoffman</name></author><author><name sortKey="O Shaughnessy, P" uniqKey="O Shaughnessy P">P. O'Shaughnessy</name></author><author><name sortKey="Lin, C L" uniqKey="Lin C">C.-L. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, S" uniqKey="Choi S">S. Choi</name></author><author><name sortKey="Yoon, S" uniqKey="Yoon S">S. Yoon</name></author><author><name sortKey="Jeon, J" uniqKey="Jeon J">J. Jeon</name></author><author><name sortKey="Zou, C" uniqKey="Zou C">C. Zou</name></author><author><name sortKey="Choi, J" uniqKey="Choi J">J. Choi</name></author><author><name sortKey="Tawhai, M H" uniqKey="Tawhai M">M.H. Tawhai</name></author><author><name sortKey="Walenga, R" uniqKey="Walenga R">R. Walenga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clift, R" uniqKey="Clift R">R. Clift</name></author><author><name sortKey="Grace, J R" uniqKey="Grace J">J.R. Grace</name></author><author><name sortKey="Weber, M E" uniqKey="Weber M">M.E. Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y. Feng</name></author><author><name sortKey="Kleinstreuer, C" uniqKey="Kleinstreuer C">C. Kleinstreuer</name></author><author><name sortKey="Castro, N" uniqKey="Castro N">N. Castro</name></author><author><name sortKey="Rostami, A" uniqKey="Rostami A">A. Rostami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferron, G A" uniqKey="Ferron G">G.A. Ferron</name></author><author><name sortKey="Kreyling, W G" uniqKey="Kreyling W">W.G. Kreyling</name></author><author><name sortKey="Haider, B" uniqKey="Haider B">B. Haider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferron, G A" uniqKey="Ferron G">G.A. Ferron</name></author><author><name sortKey="Oberdorster, G" uniqKey="Oberdorster G">G. Oberdörster</name></author><author><name sortKey="Henneberg, R" uniqKey="Henneberg R">R. Henneberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finlay, W H" uniqKey="Finlay W">W.H. Finlay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geuzaine, C" uniqKey="Geuzaine C">C. Geuzaine</name></author><author><name sortKey="Remacle, J F" uniqKey="Remacle J">J.F. Remacle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haddrell, A E" uniqKey="Haddrell A">A.E. Haddrell</name></author><author><name sortKey="Lewis, D" uniqKey="Lewis D">D. Lewis</name></author><author><name sortKey="Church, T" uniqKey="Church T">T. Church</name></author><author><name sortKey="Vehring, R" uniqKey="Vehring R">R. Vehring</name></author><author><name sortKey="Murnane, D" uniqKey="Murnane D">D. Murnane</name></author><author><name sortKey="Reid, J P" uniqKey="Reid J">J.P. Reid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hindle, M" uniqKey="Hindle M">M. Hindle</name></author><author><name sortKey="Longest, P W" uniqKey="Longest P">P.W. Longest</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofmann, W" uniqKey="Hofmann W">W. Hofmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lambert, A R" uniqKey="Lambert A">A.R. Lambert</name></author><author><name sortKey="O Shaughnessy, P T" uniqKey="O Shaughnessy P">P.T. O'Shaughnessy</name></author><author><name sortKey="Tawhai, M H" uniqKey="Tawhai M">M.H. Tawhai</name></author><author><name sortKey="Hoffman, E A" uniqKey="Hoffman E">E.A. Hoffman</name></author><author><name sortKey="Lin, C L" uniqKey="Lin C">C.-L. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li" uniqKey="Li">Li</name></author><author><name sortKey="Ahmadi, G" uniqKey="Ahmadi G">G. Ahmadi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Montassier, N" uniqKey="Montassier N">N. Montassier</name></author><author><name sortKey="Hopke, P K" uniqKey="Hopke P">P.K. Hopke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, C L" uniqKey="Lin C">C.-L. Lin</name></author><author><name sortKey="Tawhai, M H" uniqKey="Tawhai M">M.H. Tawhai</name></author><author><name sortKey="Mclennan, G" uniqKey="Mclennan G">G. McLennan</name></author><author><name sortKey="Hoffman, E A" uniqKey="Hoffman E">E.A. Hoffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longest, P W" uniqKey="Longest P">P.W. Longest</name></author><author><name sortKey="Kleinstreuer, C" uniqKey="Kleinstreuer C">C. Kleinstreuer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longest, P W" uniqKey="Longest P">P.W. Longest</name></author><author><name sortKey="Mcleskey, J T" uniqKey="Mcleskey J">J.T. McLeskey</name></author><author><name sortKey="Hindle, M" uniqKey="Hindle M">M. Hindle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longest, P W" uniqKey="Longest P">P.W. Longest</name></author><author><name sortKey="Tian, G" uniqKey="Tian G">G. Tian</name></author><author><name sortKey="Walenga, R L" uniqKey="Walenga R">R.L. Walenga</name></author><author><name sortKey="Hindle, M" uniqKey="Hindle M">M. Hindle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martonen, T B" uniqKey="Martonen T">T.B. Martonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyawaki, S" uniqKey="Miyawaki S">S. Miyawaki</name></author><author><name sortKey="Hoffman, E A" uniqKey="Hoffman E">E.A. Hoffman</name></author><author><name sortKey="Lin, C L" uniqKey="Lin C">C.-L. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyawaki, S" uniqKey="Miyawaki S">S. Miyawaki</name></author><author><name sortKey="Tawhai, M H" uniqKey="Tawhai M">M.H. Tawhai</name></author><author><name sortKey="Hoffman, E A" uniqKey="Hoffman E">E.A. Hoffman</name></author><author><name sortKey="Wenzel, S E" uniqKey="Wenzel S">S.E. Wenzel</name></author><author><name sortKey="Lin, C L" uniqKey="Lin C">C.-L. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Si, H" uniqKey="Si H">H. Si</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tawhai, M H" uniqKey="Tawhai M">M.H. Tawhai</name></author><author><name sortKey="Pullan, A J" uniqKey="Pullan A">A.J. Pullan</name></author><author><name sortKey="Hunter, P J" uniqKey="Hunter P">P.J. Hunter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vreman, A" uniqKey="Vreman A">A. Vreman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walenga, R L" uniqKey="Walenga R">R.L. Walenga</name></author><author><name sortKey="Longest, P W" uniqKey="Longest P">P.W. Longest</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winkler Heil, R" uniqKey="Winkler Heil R">R. Winkler-Heil</name></author><author><name sortKey="Ferron, G" uniqKey="Ferron G">G. Ferron</name></author><author><name sortKey="Hofmann, W" uniqKey="Hofmann W">W. Hofmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Worth Longest, P" uniqKey="Worth Longest P">P. Worth Longest</name></author><author><name sortKey="Hindle, M" uniqKey="Hindle M">M. Hindle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Worth Longest, P" uniqKey="Worth Longest P">P. Worth Longest</name></author><author><name sortKey="Xi, J" uniqKey="Xi J">J. Xi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, D" uniqKey="Wu D">D. Wu</name></author><author><name sortKey="Miyawaki, S" uniqKey="Miyawaki S">S. Miyawaki</name></author><author><name sortKey="Tawhai, M H" uniqKey="Tawhai M">M.H. Tawhai</name></author><author><name sortKey="Hoffman, E A" uniqKey="Hoffman E">E.A. Hoffman</name></author><author><name sortKey="Lin, C L" uniqKey="Lin C">C.-L. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, D" uniqKey="Wu D">D. Wu</name></author><author><name sortKey="Tawhai, M H" uniqKey="Tawhai M">M.H. Tawhai</name></author><author><name sortKey="Hoffman, E A" uniqKey="Hoffman E">E.A. Hoffman</name></author><author><name sortKey="Lin, C L" uniqKey="Lin C">C.-L. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, Y" uniqKey="Yin Y">Y. Yin</name></author><author><name sortKey="Choi, J" uniqKey="Choi J">J. Choi</name></author><author><name sortKey="Hoffman, E A" uniqKey="Hoffman E">E.A. Hoffman</name></author><author><name sortKey="Tawhai, M H" uniqKey="Tawhai M">M.H. Tawhai</name></author><author><name sortKey="Lin, C L" uniqKey="Lin C">C.-L. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Kim, C S" uniqKey="Kim C">C.S. Kim</name></author><author><name sortKey="Kleinstreuer, C" uniqKey="Kleinstreuer C">C. Kleinstreuer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Kleinstreuer, C" uniqKey="Kleinstreuer C">C. Kleinstreuer</name></author><author><name sortKey="Kim, C S" uniqKey="Kim C">C.S. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Kleinstreuer, C" uniqKey="Kleinstreuer C">C. Kleinstreuer</name></author><author><name sortKey="Kim, C S" uniqKey="Kim C">C.S. Kim</name></author><author><name sortKey="Cheng, Y S" uniqKey="Cheng Y">Y.S. Cheng</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Iowa</li><li>Maryland</li></region><settlement><li>Iowa City</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Rajaraman, Prathish K" sort="Rajaraman, Prathish K" uniqKey="Rajaraman P" first="Prathish K." last="Rajaraman">Prathish K. Rajaraman</name></region><name sortKey="Babiskin, Andrew" sort="Babiskin, Andrew" uniqKey="Babiskin A" first="Andrew" last="Babiskin">Andrew Babiskin</name><name sortKey="Choi, Jiwoong" sort="Choi, Jiwoong" uniqKey="Choi J" first="Jiwoong" last="Choi">Jiwoong Choi</name><name sortKey="Choi, Jiwoong" sort="Choi, Jiwoong" uniqKey="Choi J" first="Jiwoong" last="Choi">Jiwoong Choi</name><name sortKey="Delvadia, Renishkumar" sort="Delvadia, Renishkumar" uniqKey="Delvadia R" first="Renishkumar" last="Delvadia">Renishkumar Delvadia</name><name sortKey="Hoffman, Eric A" sort="Hoffman, Eric A" uniqKey="Hoffman E" first="Eric A." last="Hoffman">Eric A. Hoffman</name><name sortKey="Lin, Ching Long" sort="Lin, Ching Long" uniqKey="Lin C" first="Ching-Long" last="Lin">Ching-Long Lin</name><name sortKey="Lin, Ching Long" sort="Lin, Ching Long" uniqKey="Lin C" first="Ching-Long" last="Lin">Ching-Long Lin</name><name sortKey="O Shaughnessy, Patrick T" sort="O Shaughnessy, Patrick T" uniqKey="O Shaughnessy P" first="Patrick T." last="O'Shaughnessy">Patrick T. O'Shaughnessy</name><name sortKey="Rajaraman, Prathish K" sort="Rajaraman, Prathish K" uniqKey="Rajaraman P" first="Prathish K." last="Rajaraman">Prathish K. Rajaraman</name><name sortKey="Walenga, Ross" sort="Walenga, Ross" uniqKey="Walenga R" first="Ross" last="Walenga">Ross Walenga</name></country><country name="Corée du Sud"><noRegion><name sortKey="Choi, Sanghun" sort="Choi, Sanghun" uniqKey="Choi S" first="Sanghun" last="Choi">Sanghun Choi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000058 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000058 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7187883
|texte= Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32346183" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |